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KMID : 1137820220430040214
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의공학회지
2022 Volume.43 No. 4 p.214 ~ p.218
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Changes of Blood pH in Micro-circulation System on the Stimulated Time of Pulsed Magnetic Fields
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Lee Bo-Ram
Choi Yu-Kyung
Lee Hyun-Sook
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Abstract
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The purpose of this study was to investigate the role of the PMF in the treatment of acidosis and inflam- mation by monitoring the pH change for the continuity of PMF effect on the blood in the micro-circulation system that mimics the capillaries in the human body. Micro-tubes and micro-channels similar in diameter to those of arteries and arterioles were fabricated using PDMS and connected to a micro-pump for blood circulation. The continuity of PMF effect was verified in a micro-circulation system in-vitro. The pH changes for the circulating blood and for per- sistence time of PMF stimulus effect were confirmed using the optimized PMF conditions based on the previous studies. Also pH changes were observed by continuously stimulating PMF for a set period of time. The result was observed that the pH of the blood acidified using tBHP continued to rise from immediately after stimulation of PMF to 70 minutes of stimulation, reaching a normal pH range, and then decreasing. Our study showed that PMF has a positive effect on the control of blood pH homeostasis, so it is suggested the possibility of being used as a non- invasive treatment for acidosis treatment and anti- inflammatory treatment.
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KEYWORD
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Microcirculation system, PMF, pH, Blood
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